Successful rechallenge with taxanes following prophylactic ketotifen in patients who had developed severe hypersensitivity reactions
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چکیده
منابع مشابه
Successful rechallenge for oxaliplatin hypersensitivity reactions in patients with metastatic colorectal cancer.
BACKGROUND Discontinuation of oxaliplatin-containing regimens is sometimes necessary due to hypersensitivity reactions for which effective countermeasures have not yet been identified. PATIENTS AND METHODS We retrospectively reviewed cases in which hypersensitivity reactions developed in 623 patients treated with oxaliplatin for colorectal cancer. Clinical outcomes of patients who underwent o...
متن کاملSuccessful desensitization to docetaxel after severe hypersensitivity reactions in two patients.
PURPOSE Two cases of successful desensitization to docetaxel after severe hypersensitivity reactions are reported. SUMMARY Two patients with gynecological malignancies (uterine leiomyosarcoma and ovarian adenocarcinoma) experienced severe hypersensitivity reactions with docetaxel, including flushing, numbness, sharp radiating pain, severe nausea and vomiting, apnea, and unresponsiveness. Both...
متن کاملRe-visiting Hypersensitivity Reactions to Taxanes: A Comprehensive Review.
Taxanes (a class of chemotherapeutic agents) are an important cause of hypersensitivity reactions (HSRs) in cancer patients. During the last decade, the development of rapid drug desensitization has been key to allow patients with HSRs to taxanes to be safely re-treated although the mechanisms of these HSRs are not fully understood. Earlier studies suggested that solvents, such as Cremophor EL ...
متن کاملHypersensitivity reaction to high-dose methotrexate and successful rechallenge in a pediatric patient with osteosarcoma.
Hypersensitivity reactions to methotrexate are rare, but have been reported. Methotrexate has shown activity against many malignancies, and omission of methotrexate therapy may increase the risk of cancer-related death in some patients. Therefore, rechallenging patients with methotrexate following hypersensitivity may be beneficial. We report a case of a child with metastatic osteosarcoma who e...
متن کاملRechallenge to Carboplatin in Children with Low Grade Glioma and Carboplatin Hypersensitivity Reactions
Background: Carboplatin based regimens have demonstrated activity in pediatric patients with low grade gliomas (LGG). However, carboplatin hypersensitivity reactions (CHRs) may be a major problem leading to premature cessation of an effective therapy. The objectives of this study were to describe the prevalence, characteristics and management of CHR. Methods: We performed a retrospective review...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2000
ISSN: 0923-7534
DOI: 10.1023/a:1008366801690